GETTING MY PKRRATING TO WORK

The activated website enzyme then phosphorylates its important substrate, the translational initiation factor eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to some conserved loved ones of four protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in response to diverse stimuli12, triggering the built-